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Related Experiment Videos

Pathfinding and target selection by developing geniculocortical axons.

A Ghosh1, C J Shatz

  • 1Department of Neurobiology, Stanford University School of Medicine, California 94305.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|January 1, 1992
PubMed
Summary
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During mammalian brain development, lateral geniculate nucleus (LGN) axons form transient collaterals and extensively branch within the subplate. These morphological changes suggest dynamic interactions with subplate neurons are crucial for target selection in the visual cortex.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Axon Guidance

Background:

  • Thalamic axon navigation to the cerebral cortex is essential for forming neural circuits.
  • Understanding cellular interactions guiding thalamocortical axon target selection is critical.

Purpose of the Study:

  • To investigate the morphology of lateral geniculate nucleus (LGN) axons during their journey to the primary visual cortex.
  • To elucidate cellular interactions involved in cortical target selection by thalamic axons.

Main Methods:

  • Utilized the lipophilic tracer Dil to label geniculocortical axons in fixed fetal and neonatal cat brains (embryonic day 26 to postnatal day 7).
  • Examined axon morphology during navigation within the telencephalon and subplate.

Main Results:

Related Experiment Videos

  • LGN axons form transient interstitial collaterals in nonvisual cortical areas during growth (embryonic day 30-40).
  • A prolonged period exists where LGN axons reside in the visual subplate (arriving by embryonic day 36, entering layer 6 around embryonic day 50).
  • Within the visual subplate, LGN axons exhibit extensive terminal branching, a shift from earlier growth cone morphology.

Conclusions:

  • Transient axon collaterals suggest interactions with subplate neurons along the entire intracortical path.
  • Extensive branching within the subplate indicates dynamic cellular interactions, not mere waiting.
  • These findings support the necessity of thalamic axon-subplate neuron interactions for successful cortical target selection.