Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hydrogel nerve conduits produced from alginate/chitosan complexes.

Lukas A Pfister1, Michaël Papaloïzos, Hans P Merkle

  • 1Institute of Pharmaceutical Sciences, ETH Zurich, Wolfgang-Pauli Strasse 10, 8093 Zurich, Switzerland.

Journal of Biomedical Materials Research. Part A
|February 13, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Current Trends in the Implantation of the Touch Prosthesis at the Thumb Carpometacarpal Joint: Results of the 1st German-Speaking User Meeting].

Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V...·2024
Same author

PLGA-particle vaccine carrying TLR3/RIG-I ligand Riboxxim synergizes with immune checkpoint blockade for effective anti-cancer immunotherapy.

Nature communications·2021
Same author

Photochemical internalization (PCI)-mediated activation of CD8 T cells involves antigen uptake and CCR7-mediated transport by migratory dendritic cells to draining lymph nodes.

Journal of controlled release : official journal of the Controlled Release Society·2021
Same author

FOXO1 gene involvement in a non-rhabdomyosarcomatous neoplasm.

Virchows Archiv : an international journal of pathology·2021
Same author

Combined Photosensitization and Vaccination Enable CD8 T-Cell Immunity and Tumor Suppression Independent of CD4 T-Cell Help.

Frontiers in immunology·2019
Same author

Surface-assembled poly(I:C) on PEGylated PLGA microspheres as vaccine adjuvant: APC activation and bystander cell stimulation.

International journal of pharmaceutics·2016

Biodegradable nerve conduits (NCs) made from alginate and chitosan hydrogels offer a promising solution for peripheral nerve repair. These NCs demonstrate excellent water uptake, nutrient exchange, and mechanical properties for effective surgical handling and nerve regeneration.

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Polymer Chemistry

Background:

  • Peripheral nerve injuries often require advanced treatments beyond conventional methods.
  • Nerve conduits (NCs) are emerging as a viable alternative for peripheral nerve repair.
  • Effective NC materials must be biodegradable, mechanically sound, and facilitate nutrient exchange.

Purpose of the Study:

  • To develop and characterize biodegradable nerve conduits (NCs) using a hydrogel composed of alginate and chitosan.
  • To evaluate the physical and mechanical properties of the developed alginate/chitosan NCs for peripheral nerve repair applications.

Main Methods:

  • Fabrication of biodegradable NCs from oppositely charged polysaccharides: alginate and chitosan.
  • Characterization of NCs through swelling studies, rheological measurements, and permeation assays.

Related Experiment Videos

  • Assessment of mechanical properties, including storage modulus and tear resistance.

    • Main Results:

    • The alginate/chitosan NCs exhibited high water uptake (84% w/w).
    • Permeation studies confirmed the exchange of fluorescent-labeled dextrans in a molecular weight-dependent manner.
    • The NCs met mechanical specifications without additional crosslinking, showing a storage modulus of approximately 40 kPa and remarkable tear resistance, ensuring easy surgical handling and preventing nerve compression.

    Conclusions:

    • Biodegradable alginate/chitosan hydrogel-based nerve conduits offer a promising material for peripheral nerve repair.
    • The developed NCs possess favorable swelling, permeation, and mechanical properties suitable for clinical application.
    • These NCs provide a balance of softness to prevent nerve compression and sufficient strength for surgical manipulation and tissue regeneration.