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Updated: Jul 17, 2026

Mouse In Vivo Placental Targeted CRISPR Manipulation
Published on: April 14, 2023
[Action of corticotropin-releasing hormone on its own receptor type-1 in human placenta]
Xiao-dong Wang1, Hai-yan Yu, Mao-mao He
1Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu 610041, China.
Objective:
To investigate the expression of corticotropin-releasing hormone and its receptor type-1 in human placental tissues during caesarian operations.
Methods:
IHC-SP staining and ISH methods were adopted to identify the expression patterns of CRH and its receptor CRH-R1 in the placenta taken from the women who had uncomplicated pregnancies. The placental tissues were collected after caesarian operations on the women with threatened labor.
Results:
Positive expressions of both CRH and CRH-R1 messenger ribonucleic acid and peptide were found in the placental tissues, but the later was stronger (P<0.05).
Conclusion:
The elevated level of placental CRH may be a trigger of the transcription of its own receptor CRH-R1 during caesarian operations. This positive feedback of CRH on its own receptor may represent a functional adaptation of human utero-plcental-fetal unit in responding to stress.
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