Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Experimental immunosuppression induced by herpes simplex virus.

R Cappel, C Henry, L Thiry

    Archives of Virology
    |January 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Goat and cow-milk based infant formulas contain extracellular vesicles with different miRNA and protein cargo.

    Current research in food science·2026
    Same author

    Financial Toxicity in Cervical Cancer Patients Undergoing Radical Treatment With External Beam Radiation and Brachytherapy at a Tertiary New Zealand Radiation Oncology Centre.

    Journal of medical imaging and radiation oncology·2026
    Same author

    Evaluation of the reproducibility and factors affecting perfusion measurement in normal pregnancies with single-slice FAIR Arterial Spin Labeling (ASL).

    Placenta·2026
    Same author

    Characterization of extracellular vesicles at parturition in dairy cows with late-gestation heat stress.

    JDS communications·2026
    Same author

    Family History and Solar Insolation in Bipolar I Disorder.

    Acta psychiatrica Scandinavica·2026
    Same author

    Chronic meningoencephalitis due to enterovirus A71 complicating rituximab therapy.

    Revue neurologique·2025

    Herpes simplex virus infection suppresses the cell-mediated immune response in mice, evidenced by lymphocyte unresponsiveness. The immunostimulant levamisole did not reverse this immunosuppression.

    Area of Science:

    • Immunology
    • Virology
    • Infectious Diseases

    Background:

    • Herpes simplex virus (HSV) infections can impact the host immune system.
    • Understanding the effects of viral infections on cell-mediated immunity is crucial for developing effective treatments.

    Purpose of the Study:

    • To investigate the impact of experimental herpetic infection on cell-mediated immune responses in mice.
    • To evaluate the potential of levamisole in counteracting HSV-induced immunosuppression.

    Main Methods:

    • Induction of experimental herpetic infection in a mouse model.
    • Assessment of lymphocyte responsiveness to phytohemagglutinin (PHA) stimulation in vitro.
    • Evaluation of susceptibility to secondary infections, specifically Coxsackie B virus.

    Related Experiment Videos

    Main Results:

    • Herpes simplex virus infection led to significant immunosuppression in mice.
    • Lymphocytes from infected mice showed unresponsiveness to PHA stimulation.
    • Mice infected with HSV exhibited increased susceptibility to Coxsackie B virus.
    • The immunostimulant drug levamisole did not restore lymphocyte responsiveness to PHA.

    Conclusions:

    • Herpes simplex virus induces a profound immunosuppressive state in mice, affecting T-cell function.
    • This immunosuppression increases susceptibility to other viral infections.
    • Levamisole is ineffective in reversing HSV-induced lymphocyte unresponsiveness.