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Clozapine-associated priapism: a case report.

A D Seftel¹, I Saenz de Tejada, B Szetela

¹Department of Urology, Boston University Medical Center, Massachusetts 02118.

The Journal of Urology

|January 1, 1992

Summary

Priapism, a rare side effect of antipsychotics, was observed with clozapine, an atypical antipsychotic. This case highlights potential risks even with newer psychiatric medications.

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Area of Science:

Psychiatry
Pharmacology
Urology

Background:

Antipsychotic medications are used to treat psychosis.
Atypical antipsychotics, like clozapine, were developed to reduce extrapyramidal side effects.
Priapism is a known, albeit uncommon, side effect of some antipsychotic therapies.

Observation:

A patient developed veno-occlusive priapism while undergoing treatment with clozapine.
This is the first reported instance of priapism associated with atypical antipsychotic therapy.

Findings:

The priapism episode in this case was complicated by recurrent post-ischemic priapism.
This suggests a potential link between clozapine and the development of priapism.

Implications:

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Clinicians should be aware of the potential for priapism with clozapine use.
Further research is needed to understand the mechanisms and prevalence of this adverse event.