Experimental elicitation with hydroxyisohexyl-3-cyclohexene carboxaldehyde-containing deodorants
Pia Haslund Jørgensen1, Charlotte Devantier Jensen, Suresh Rastogi
1National Allergy Research Center, Department of Dermatology, Gentofte Hospital, University of Copenhagen, Denmark.
Contact Dermatitis
|February 14, 2007
Summary
Hydroxyisohexyl-3-cyclohexene carboxaldehyde (HICC), a common allergen in deodorants, frequently causes allergic contact dermatitis. This study found that even low concentrations of HICC in deodorants can elicit reactions in sensitized individuals.
Area of Science:
- Dermatology
- Allergology
- Toxicology
Background:
- Hydroxyisohexyl-3-cyclohexene carboxaldehyde (HICC), also known as Lyral, is a prevalent allergen.
- HICC is incorporated into over 50% of commercially available deodorants.
Purpose of the Study:
- To ascertain the elicitation thresholds for HICC under conditions simulating actual deodorant application.
- To evaluate the potential of HICC in deodorants to induce allergic contact dermatitis.
Main Methods:
- Fifteen patients with confirmed HICC allergy underwent patch testing with HICC-containing and HICC-free deodorants.
- A use test was conducted on patients and 10 healthy controls using deodorants with escalating HICC concentrations (200, 600, 1800 ppm) over six weeks.
- Reactions were monitored to determine the threshold concentration causing dermatitis.
Main Results:
- All 14 patients who completed the study developed unilateral eczema when using HICC-containing deodorants; controls showed no reactions (P=0.004).
- Nine out of 14 patients exhibited positive reactions within two weeks to deodorant with 200 ppm HICC.
- Significant positive correlations were observed between the onset of positive use tests and patch test thresholds for HICC solutions and scented deodorants.
Conclusions:
- HICC is confirmed to elicit allergic contact dermatitis in a substantial percentage of sensitized individuals.
- Commonly used concentrations of HICC in deodorants are sufficient to trigger reactions in susceptible individuals.
- The findings highlight the need for careful consideration of HICC in deodorant formulations due to its allergenic potential.
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