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Updated: Jul 17, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
[Stress in mothers of individuals with autistic spectrum disorders]
Pilar Pozo Cabanillas1, Encarnación Sarriá Sánchez, Laura Méndez Zaballos
1Universidad Nacional de Educación a Distancia, Madrid, Spain. ppozo@bec.uned.es
The aim of this study was to analyze maternal stress in families of individuals with autism. We proposed a multi-factorial and global model based on the Double ABCX model of family stress (McCubbin & Patterson, 1983) in which, the factor aA (stressor) interacts with bB (social support) and cC (perception of stress or, in our study, sense of coherence, SOC) to produce the dependent factor xX (level of stress). Thirty-nine mothers with children diagnosed on Autistic Spectrum disorders completed four questionnaires relating to the factors. The data were statistically analyzed using path analysis. The results showed that the empirical data fitted the theoretically proposed model well. There existed a direct and positive relationship between stressor and stress. Social support and SOC had a direct and negative relationship to stress, and functioned as modulating variables.
The aim of this study was to analyze maternal stress in families of individuals with autism. We proposed a multi-factorial and global model based on the Double ABCX model of family stress (McCubbin & Patterson, 1983) in which, the factor aA (stressor) interacts with bB (social support) and cC (perception of stress or, in our study, sense of coherence, SOC) to produce the dependent factor xX (level of stress). Thirty-nine mothers with children diagnosed on Autistic Spectrum disorders completed four questionnaires relating to the factors. The data were statistically analyzed using path analysis. The results showed that the empirical data fitted the theoretically proposed model well. There existed a direct and positive relationship between stressor and stress. Social support and SOC had a direct and negative relationship to stress, and functioned as modulating variables.
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