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Related Experiment Videos

Feline calicivirus.

Alan D Radford1, Karen P Coyne, Susan Dawson

  • 1University of Liverpool Veterinary Teaching Hospital, Leahurst, Chester High Road, Neston, S. Wirral, CH64 7TE, United Kingdom. alanrad@liv.ac.uk

Veterinary Research
|February 14, 2007
PubMed
Summary
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Feline calicivirus (FCV) is a highly adaptable RNA virus causing diverse feline diseases. Its genetic variability challenges vaccine efficacy and control, necessitating further research into virulent strains and persistent infections.

Area of Science:

  • Veterinary Virology
  • Feline Infectious Diseases
  • Molecular Biology

Background:

  • Feline calicivirus (FCV) is a prevalent RNA virus in cats, belonging to the Caliciviridae family.
  • FCV exhibits high genome plasticity due to polymerase error rates, enabling rapid adaptation to environmental pressures.
  • This adaptability results in diverse clinical presentations, from mild respiratory illness to severe systemic disease.

Purpose of the Study:

  • To summarize the current understanding of FCV biology, pathogenesis, and epidemiology.
  • To highlight the challenges posed by FCV's genetic diversity, including emerging virulent strains and vaccine limitations.
  • To underscore the importance of persistent carriers in FCV epidemiology.

Main Methods:

  • Review of existing literature on Feline Calicivirus.

Related Experiment Videos

  • Analysis of FCV's genetic diversity and evolutionary mechanisms.
  • Examination of clinical manifestations and pathogenesis of FCV infections.

    • Main Results:

    • FCV causes a spectrum of diseases, including mild oral/respiratory signs, acute lameness, and highly virulent systemic infections.
    • Persistent infections occur in a subset of recovered cats, crucial for viral epidemiology and immune evasion.
    • Current vaccines reduce clinical disease incidence but do not prevent infection or persistent carriage, with variable efficacy against different strains.

    Conclusions:

    • FCV's genetic variability is a significant factor in feline health and disease control.
    • Future efforts must address controlling viral variability, particularly concerning emerging virulent strains and improving vaccination strategies.
    • Understanding persistent FCV infections is key to managing the virus in feline populations.