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Related Concept Videos

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions01:24

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...
Dosage Regimen: Fixed Dose01:01

Dosage Regimen: Fixed Dose

Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
Drug Accumulation During Multiple Dosing: Repetitive IV Injections01:21

Drug Accumulation During Multiple Dosing: Repetitive IV Injections

Calculating drug dosage and accumulation in multiple-dose regimens is crucial for achieving therapeutic efficacy while avoiding toxicity. This involves determining the plasma drug concentrations over time to optimize dosing schedules. The principle of superposition is fundamental in this process, allowing for the prediction of drug concentration in plasma following multiple doses based on single-dose data.The principle of superposition asserts that the plasma concentration-time curves from...
Dosage Regimen: Individualization01:24

Dosage Regimen: Individualization

Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
Rational Dosage Regimen: Maintenance Dose and Loading Dose01:24

Rational Dosage Regimen: Maintenance Dose and Loading Dose

A rational dosage regimen considers a drug's pharmacokinetics, including its absorption, distribution, metabolism, and elimination from the body. By understanding these factors, the appropriate dosage can be determined, and the dosing schedule can be designed to achieve and maintain the desired therapeutic effect while minimizing adverse effects.
In most cases, drugs are administered repetitively or infused continuously to maintain a steady-state concentration in the body. At a steady state,...
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Determination of Multiple Dosing Parameters: Loading and Maintenance Doses

A loading dose is an essential pharmacological strategy to rapidly achieve the target plasma drug concentration necessary for an immediate therapeutic effect. This approach is especially critical for drugs characterized by slow absorption or extended half-lives, where delaying therapeutic plasma levels could compromise treatment outcomes. By administering a loading dose, clinicians ensure a prompt onset of drug action, even for agents with complex pharmacokinetic profiles.Achieving steady-state...

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The relation between intermittent dosing and adherence: preliminary insights.

Margaret E Kruk1, Nina Schwalbe

  • 1School of Public Health, University of Michigan, Ann Arbor, Michigan 48109-2029, USA. mkruk@umich.edu

Clinical Therapeutics
|February 14, 2007
PubMed
Summary

Intermittent dosing, such as once-weekly schedules, may improve patient adherence to medication compared to daily regimens. While once-weekly dosing showed higher adherence, once-monthly dosing had similar results to daily schedules.

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Area of Science:

  • Pharmacotherapy
  • Patient Adherence Research
  • Drug Dosing Regimen Analysis

Background:

  • Increasing use of intermittent drug dosing schedules (less than daily).
  • Assumption that less frequent dosing improves patient convenience and adherence.
  • Lack of prior studies on the adherence impact of intermittent dosing.

Purpose of the Study:

  • To investigate the existing evidence on the effect of intermittent dosing on patient adherence.
  • To compare adherence rates between intermittently dosed and more frequently dosed medications.

Main Methods:

  • Systematic literature search of MEDLINE and International Pharmaceutical Abstracts (2000-2005).
  • Search terms included 'intermittent dosing', 'adherence', 'compliance', 'dosing schedule', and 'dosing regimen'.
  • Included head-to-head trials comparing older, more frequent dosing agents with newer intermittent agents, and patient preference studies.

Main Results:

  • Eleven trials met the expanded inclusion criteria.
  • Adherence was higher for intermittently dosed agents (8.8%-12.0% higher for weekly vs. daily).
  • Once-monthly dosing showed similar adherence to once-daily dosing over one year (87.4% vs. 86.6%).
  • Patient preference favored intermittent dosing (61%-96% preferred).

Conclusions:

  • Once-weekly dosing is associated with improved patient adherence compared to once-daily dosing.
  • Once-monthly dosing demonstrated similar adherence rates to once-daily dosing in one study.
  • Patient preference for intermittent dosing suggests potential for improved adherence.