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Updated: Jul 17, 2026

A Rat Model of EcoHIV Brain Infection
Published on: January 21, 2021
Neuropsychological abnormalities in patients with dementia in CRF 01_AE HIV-1 infection
V G Valcour1, P Sithinamsuwan, S Nidhinandana
1Hawaii AIDS Clinical Research Program, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA. Vvalcour@hawaii.edu
Abstract:
HIV-associated dementia (HAD) is not firmly established in patients with circulating recombinant form (CRF) 01_AE HIV-1. In this study, we compared neuropsychological performance among 15 Thai individuals with HAD, 15 Thai individuals without HAD, and 30 HIV-negative control subjects. HIV-1 participants were highly active anti-retroviral therapy naive and matched by age, education, and CD4 count. Neuropsychological testing abnormalities were identified in most cognitive domains among HAD vs HIV-negative participants, confirming the presence of HAD in CRF01_AE.
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