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Cognitive aging, executive function, and fractional anisotropy: a diffusion tensor MR imaging study.

S M Grieve1, L M Williams, R H Paul

  • 1The Brain Resource International Database, The Brain Resource Company, Ultimo, Australia. sgrieve@gmp.usyd.edu.au

AJNR. American Journal of Neuroradiology
|February 14, 2007
PubMed
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Fractional anisotropy (FA) in brain regions like the frontal lobe declines with age, correlating with reduced executive function. This finding suggests FA may help detect age-related cognitive changes early.

Area of Science:

  • Neuroimaging
  • Cognitive Neuroscience
  • Brain Aging Research

Background:

  • Fractional anisotropy (FA) from diffusion tensor imaging (DTI) quantifies brain connectivity.
  • Cognitive function naturally changes with age, but the underlying structural basis requires further exploration.

Purpose of the Study:

  • To investigate the relationship between FA and cognitive measures in a broad age range.
  • To explore the structural underpinnings of age-related cognitive decline.

Main Methods:

  • Generated FA images from DTI data in 87 healthy adults (20-73 years).
  • Employed regional and voxel-based analyses to examine FA-cognition relationships.

Main Results:

  • Significant negative association between age and FA in frontal, parietal, and temporal lobes (not occipital).

Related Experiment Videos

  • FA declined ~3% per decade in prefrontal regions.
  • Lower FA in frontal, temporal, and parietal lobes correlated with poorer executive function and attention.

    • Conclusions:

    • Demonstrated a link between FA and executive function, a key aspect of cognitive aging.
    • FA may serve as an early indicator for age-related cognitive changes.
    • Further prospective studies are needed to validate these findings.