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Related Experiment Videos

Differences in brain structure in deaf persons on MR imaging studied with voxel-based morphometry.

D K Shibata1

  • 1Department of Radiology, University of Washington Medical Center, Seattle, Wash, USA. shibatad@u.washington.edu

AJNR. American Journal of Neuroradiology
|February 14, 2007
PubMed
Summary

Early deafness causes significant brain anatomy changes, particularly in the left superior temporal gyrus white matter. These findings suggest structural alterations in auditory and speech pathways due to congenital hearing loss.

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Area of Science:

  • Neuroscience
  • Neuroimaging
  • Auditory Neuroscience

Background:

  • Early sensory deprivation can alter brain structure and function.
  • Gross anatomical effects of early-onset deafness are not fully understood.
  • Voxel-based morphometry (VBM) is a key tool for analyzing brain structure differences.

Purpose of the Study:

  • To compare brain anatomy in prelingually deaf individuals versus hearing controls using VBM.
  • To investigate potential hypoplasia in temporal lobe regions associated with hearing and speech in deaf subjects.
  • To test the hypothesis that early deafness leads to structural brain alterations.

Main Methods:

  • Volumetric T1-weighted MRI scans from 53 deaf and 51 hearing participants were analyzed.
  • VBM was employed for spatial normalization and segmentation of brain images.

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  • Statistical parametric mapping identified voxel-wise differences and asymmetries between groups.

    • Main Results:

    • A significant white matter deficit was observed in the left posterior superior temporal gyrus (STG) of deaf individuals.
    • This deficit was located inferior to the auditory cortex, suggesting impacts on auditory/speech tracts.
    • While overall gray matter asymmetries were similar, a loss of asymmetry was noted in the posterior STG white matter in deaf subjects.

    Conclusions:

    • Early deafness results in observable gross anatomical changes in the brain.
    • The identified white matter deficit in the left posterior STG supports the hypothesis of hypoplasia in auditory/speech pathways.
    • Despite localized changes, major hemispheric asymmetries appear largely preserved in early deafness.