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Clonorchiasis-associated perforated eosinophilic cholecystitis

Chung-Hsu Lai1, Chuen Chin, Hsing-Chun Chung

  • 1Department of Infectious Diseases, E-Da Hospital/I-Shou University, Kaohsiung County, Taiwan, Republic of China. laich6363@yahoo.com.tw

The American Journal of Tropical Medicine and Hygiene
|February 14, 2007
PubMed

Insights

Clonorchiasis, a liver fluke infection, can cause gallbladder inflammation. This rare case highlights perforated eosinophilic cholecystitis as a complication of Clonorchis sinensis infection.

Area of Science:

  • Hepatology and Tropical Medicine
  • Gastroenterology
  • Parasitology

Background:

  • Clonorchiasis, caused by the liver fluke Clonorchis sinensis, is prevalent in East Asia.
  • Chronic Clonorchis sinensis infection frequently leads to biliary complications like cholelithiasis and cholangitis.
  • Cholecystitis is a known complication, but eosinophilic infiltration is an uncommon cause.

Observation:

  • A rare case of perforated eosinophilic cholecystitis associated with Clonorchis sinensis infection is presented.
  • The patient exhibited symptoms indicative of acute cholecystitis.
  • Histopathological examination revealed significant eosinophilic infiltration of the gallbladder wall.

Findings:

  • This case underscores a rare presentation of cholecystitis in clonorchiasis.
  • Eosinophilic infiltration, though infrequent, can be a significant factor in the pathogenesis of cholecystitis in this parasitic infection.
  • The perforation suggests a severe inflammatory response.

Implications:

  • Highlights the importance of considering parasitic infections in the differential diagnosis of cholecystitis, especially in endemic regions.
  • Suggests that eosinophilic infiltration may play a role in the severity of biliary complications in clonorchiasis.
  • Emphasizes the need for further research into the immunopathology of Clonorchis sinensis-associated biliary disease.

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