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Clonorchiasis-associated perforated eosinophilic cholecystitis.
Chung-Hsu Lai1, Chuen Chin, Hsing-Chun Chung
1Department of Infectious Diseases, E-Da Hospital/I-Shou University, Kaohsiung County, Taiwan, Republic of China. laich6363@yahoo.com.tw
The American Journal of Tropical Medicine and Hygiene
|February 14, 2007
Summary
Clonorchiasis, a liver fluke infection, can cause gallbladder inflammation. This rare case highlights perforated eosinophilic cholecystitis as a complication of Clonorchis sinensis infection.
Area of Science:
- Hepatology and Tropical Medicine
- Gastroenterology
- Parasitology
Background:
- Clonorchiasis, caused by the liver fluke Clonorchis sinensis, is prevalent in East Asia.
- Chronic Clonorchis sinensis infection frequently leads to biliary complications like cholelithiasis and cholangitis.
- Cholecystitis is a known complication, but eosinophilic infiltration is an uncommon cause.
Observation:
- A rare case of perforated eosinophilic cholecystitis associated with Clonorchis sinensis infection is presented.
- The patient exhibited symptoms indicative of acute cholecystitis.
- Histopathological examination revealed significant eosinophilic infiltration of the gallbladder wall.
Findings:
- This case underscores a rare presentation of cholecystitis in clonorchiasis.
- Eosinophilic infiltration, though infrequent, can be a significant factor in the pathogenesis of cholecystitis in this parasitic infection.
- The perforation suggests a severe inflammatory response.
Implications:
- Highlights the importance of considering parasitic infections in the differential diagnosis of cholecystitis, especially in endemic regions.
- Suggests that eosinophilic infiltration may play a role in the severity of biliary complications in clonorchiasis.
- Emphasizes the need for further research into the immunopathology of Clonorchis sinensis-associated biliary disease.
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