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Hitting the numbers: the emerging network of p63 targets
M Alessandra Viganò1, Roberto Mantovani
1Dipartimento di Scienze Biomolecolari e Biotecnologie, Università degli Studi di Milano, Milano, Italy. alessandra.vigano@guest.unimi.it
Abstract:
p63 is a transcription factor with a "master" role in the asymmetric cell division of stratified epithelia. The transcriptional strategy is exerted by activating and repressing a wide range of genes. Our understanding of the pathways and networks controlled by p63 is starting to emerge, thanks to profiling arrays and ChIP on chip experiments. We discuss recent advancements in the identification of bona fide targets, which suggests that several independent, as well as interconnected pathways are controlled by p63. Not surprisingly, the list includes genes previously shown to play a key role in differentiation processes, as well as targets involved in cell cycle control, signaling and transcription.
Insights
The p63 transcription factor regulates stratified epithelial cell division and gene expression. Recent studies identify its targets, revealing control over differentiation, cell cycle, and signaling pathways.
Area of Science:
- Molecular Biology
- Developmental Biology
- Cell Biology
Background:
- p63 is a crucial transcription factor in stratified epithelia.
- It plays a master role in asymmetric cell division.
- p63 regulates gene expression through activation and repression.
Purpose of the Study:
- To explore the pathways and networks controlled by p63.
- To identify bona fide gene targets of p63.
- To understand the role of p63 in cellular processes.
Main Methods:
- Utilizing profiling arrays.
- Employing ChIP on chip experiments.
- Analyzing gene expression data.
Main Results:
- Emerging understanding of p63-controlled pathways and networks.
- Identification of several independent and interconnected pathways regulated by p63.
- p63 targets include genes involved in differentiation, cell cycle control, signaling, and transcription.
Conclusions:
- p63 controls a wide range of genes essential for epithelial development.
- Its targets highlight roles in differentiation and cell fate determination.
- Further research into p63 networks will illuminate epithelial biology.
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