Related Experiment Video

Updated: Jul 17, 2026

Establishment of the Dual Humanized TK-NOG Mouse Model for HIV-associated Liver Pathogenesis
10:12

Establishment of the Dual Humanized TK-NOG Mouse Model for HIV-associated Liver Pathogenesis

Published on: September 11, 2019

Liver transplantation in HIV-HCV coinfected patients: a case-control study

Lluis Castells1, Alfredo Escartín, Itxarone Bilbao

  • 1Liver Unit, Department of Internal Medicine, Hospital Universitari Vall d'Hebrón, Universidad Autónoma de Barcelona, Barcelona, Spain.

Transplantation
|February 14, 2007
PubMed

Insights

Liver transplantation outcomes for patients with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) coinfection are comparable to those without HIV. Short- to midterm results show excellent survival rates and similar rejection rates in both groups.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Transplantation Medicine

Background:

  • Hepatitis C virus (HCV)-associated cirrhosis is a leading indication for liver transplantation (LT).
  • Human immunodeficiency virus (HIV) infection presents unique challenges in post-transplant management, particularly regarding immunosuppression and viral coinfections.

Purpose of the Study:

  • To compare the outcomes of liver transplantation in HIV-infected patients coinfected with HCV to those of non-HIV infected patients.
  • To evaluate acute cellular rejection, patient survival, HCV recurrence, and response to antiviral therapy in HIV-HCV coinfected liver transplant recipients.

Main Methods:

  • Retrospective comparison of nine HIV-HCV coinfected patients undergoing LT with a control group of non-HIV patients transplanted before and after each HIV patient.
  • Standard immunosuppression protocols using tacrolimus with steroids or mycophenolate mofetil were employed.
  • Post-transplant outcomes including rejection rates, patient survival, HCV recurrence, and antiviral treatment response were analyzed.

Main Results:

  • Acute cellular rejection rates were 44% in the HIV group versus 22% in the control group (P=NS).
  • Three-year actuarial patient survival was 87.5% in the HIV group and 93.7% in the control group (P=NS).
  • HCV recurrence occurred earlier and was more cholestatic in the HIV group, with sustained virologic response rates of 20% in the HIV group and 11.1% in the control group (P=NS) after antiviral treatment.

Conclusions:

  • Short- to midterm results of liver transplantation in HIV-HCV coinfected patients are excellent and comparable to non-HIV infected patients.
  • While HCV recurrence may be more aggressive in coinfected patients, outcomes remain favorable with appropriate management.
  • Liver transplantation is a viable option for carefully selected HIV-HCV coinfected patients.

More Related Videos

Vascular Reconstruction with the Cuff Technique in Mouse Orthotopic Liver Transplantation05:25

Vascular Reconstruction with the Cuff Technique in Mouse Orthotopic Liver Transplantation

Published on: December 1, 2023

Related Concept Videos

Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...