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Updated: Jul 17, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Androgen receptor and prostate cancer
E Richter1, S Srivastava, A Dobi
1Center for Prostate Disease Research, Department of Surgery, US Military Cancer Institute, Uniformed Services University, Rockville, MD 20852, USA.
Androgen receptor (AR) is crucial in prostate cancer (CaP) development and treatment. Understanding AR dysfunctions and its network is key for developing advanced CaP therapies.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Prostate cancer (CaP) is androgen-dependent, making androgen ablation therapy a standard treatment.
- The androgen receptor (AR) plays a critical role in CaP development, progression, and treatment response.
- AR's function evolves, leading to androgen-independent states and therapeutic challenges.
Purpose of the Study:
- To review the salient features of the androgen receptor (AR).
- To highlight recent advances in understanding AR dysfunctions in prostate cancer (CaP).
- To emphasize the importance of AR knowledge for future CaP therapeutic development.
Main Methods:
- Literature review focusing on AR function in prostate cancer.
- Analysis of recent discoveries regarding AR regulation and genomic rearrangements.
- Examination of AR's role in both androgen-dependent and -independent CaP states.
Main Results:
- Overexpression of ETS-related proto-oncogenes may be AR-driven due to genomic rearrangements, offering insights into early CaP.
- AR function changes as cancer cells become androgen-independent.
- Current therapeutic strategies for CaP revolve around manipulating the androgen pathway and AR.
Conclusions:
- A comprehensive understanding of AR function, regulation, and abnormalities is vital for advancing CaP treatment.
- Further research into AR dysfunctions and its network will facilitate the development of novel CaP therapies.
- Targeting AR and its associated pathways remains a central strategy in managing advanced prostate cancer.
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