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Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

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Aggrenox-associated acute interstitial nephritis.

Abdullah Al Hwiesh1

  • 1King Fahad University Hospital, Al Khober, Kingdom of Saudi Arabia.

Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia
|February 14, 2007
PubMed
Summary

A rare case of acute interstitial nephritis (AIN) linked to Aggrenox, a combination of aspirin and dipyridamole, is reported. Discontinuation of Aggrenox led to significant renal recovery in this patient.

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Area of Science:

  • Nephrology
  • Pharmacology
  • Internal Medicine

Background:

  • Acute interstitial nephritis (AIN) is an inflammation of the kidney.
  • Aggrenox is a combination drug containing aspirin and dipyridamole.
  • AIN associated with Aggrenox has not been previously documented.

Purpose of the Study:

  • To report a novel case of AIN.
  • To investigate the potential link between Aggrenox and AIN.
  • To describe the clinical course and management of AIN induced by Aggrenox.

Main Methods:

  • Case report of an 83-year-old male patient.
  • Clinical presentation, laboratory findings, and renal biopsy were analyzed.
  • Treatment involved drug discontinuation and supportive care.

Main Results:

  • The patient developed AIN four days after initiating Aggrenox.
  • Renal biopsy confirmed AIN.
  • Serum creatinine levels improved significantly after Aggrenox withdrawal.

Conclusions:

  • Aggrenox may cause acute interstitial nephritis.
  • Discontinuation of Aggrenox is crucial for recovery.
  • Further studies are warranted to determine the prevalence of Aggrenox-induced AIN.