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Updated: Jul 17, 2026
A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
Published on: June 18, 2018
Environmental modulation of cocaine self-administration in the rat
Daniele Caprioli1, Giovanna Paolone, Michele Celentano
1Department of Human Physiology and Pharmacology, University of Rome Sapienza, 5 Piazzale Aldo Moro, 00185, Rome, Italy.
Rationale:
Previous studies have shown that environmental context can powerfully modulate the induction of psychomotor sensitization to cocaine in the rat. Rats that receive repeated administrations of cocaine in association with environmental novelty exhibit greater psychomotor sensitization than animals that receive the same treatments in their home cages.
Objectives:
The goal of the present study was to investigate whether environmental context can exert its modulatory influence also on cocaine self-administration.
Materials And Methods:
Independent groups of rats with intravenous catheters were given the possibility to self-administer different doses of cocaine (0.0, 0.2, 0.4, and 0.8 mg/kg per infusion) under two environmental conditions. Some animals were housed in the self-administration cages (home groups), whereas other rats were transported to the self-administration cages only for the test sessions (novelty groups).
Results:
Environmental "novelty" facilitated the acquisition of cocaine self-administration at the doses of 0.2 and 0.4 mg/kg per infusion. When rats were given access to a higher dose of cocaine (0.8 mg/kg per infusion), there were no significant group differences in drug taking. Environmental context had no effect on the self-administration of the vehicle. Thus, it appears that environmental "novelty" produced a shift to the left in the dose-effect curve for cocaine self-administration. Furthermore, "novelty" enhanced the motivation of the rats to work for cocaine, as indicated by the results of a progressive ratio procedure.
Conclusions:
The present findings demonstrate for the first time that the environment surrounding drug taking can alter both the intake of and motivation for cocaine.
