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Irritable Bowel Syndrome

Irritable Bowel Syndrome

DefinitionIrritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by recurrent combinations of abdominal pain, bloating, diarrhea, or constipation.Pathophysiology of irritable bowel syndromeIts pathophysiology is multifactorial, involving disturbances in motility, sensory processing, microbial balance, barrier integrity, and gut–brain communication. These mechanisms interact to produce symptoms that vary across IBS subtypes.Altered Motility PatternsDisordered...

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...

Inflammatory Bowel Disease I: Introduction

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:

Chronic Bowel Disorders: Introduction

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

Inflammatory Bowel Disease II: Ulcerative Colitis

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...

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Related Experiment Video

Updated: Jul 17, 2026

A Rat Model of Pouchitis Following Proctocolectomy and Ileal Pouch-Anal Anastomosis Using Dextran Sulfate Sodium

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Published on: May 31, 2024

[Postinfectious irritable bowel syndrome].

Zoltán Döbrönte¹, Lilla Lakner, Krisztina Sarang

¹Vas Megye és Szombathely Megyei Jogú Város Markusovszky Kórháza, Oktatókórház, Gasztroenterológiai és Belgyógyászati Osztály, Szombathely. dobronte.zoltan@markusovszky.hu

|February 15, 2007

Summary

Postinfectious irritable bowel syndrome (IBS) can develop after bacterial gastroenteritis, increasing risk. Pathophysiology involves gut-nervous system and immune responses, with stress worsening symptoms.

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Chronic Salmonella Infection Induced Intestinal Fibrosis

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Area of Science:

Gastroenterology
Immunology
Neurogastroenterology

Context:

Postinfectious irritable bowel syndrome (IBS) is a distinct subtype of IBS.
Bacterial gastroenteritis significantly elevates the risk of developing IBS within a year.
Diarrhea-predominant IBS is the most common clinical manifestation.

Purpose:

To elucidate the pathophysiological mechanisms underlying postinfectious IBS.
To explore the roles of the enteric nervous system, immune system, and brain-gut interactions.

Summary:

Postinfectious IBS involves enteric nervous system defects, leading to visceral hypersensitivity and altered intestinal motility.
Immune system involvement is evidenced by increased T lymphocytes and an altered cytokine profile.
Brain-gut interactions, stress, and potential alterations in gut microbiota contribute to symptom development.

Impact:

Understanding these mechanisms can guide future therapeutic strategies for postinfectious IBS.
Current treatments for postinfectious IBS are similar to idiopathic IBS, with limited evidence for antibiotics or probiotics.
Further research is needed to clarify the relationship between IBS and small intestinal bacterial overgrowth.