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Updated: Jul 17, 2026

Characterization of Synthetic Polymers via Matrix Assisted Laser Desorption Ionization Time of Flight (MALDI-TOF) Mass Spectrometry
Published on: June 10, 2018
Quantitative interpretation of MALDI-TOF mass spectra of imperfect carbosilane dendrimers
Alena Krupkova1, Jan Cermak, Zuzana Walterova
1Institute of Chemical Process Fundamentals, Academy of Sciences of the Czech Republic, Rozvojová 2, 16502 Prague 6, Czech Republic.
Abstract:
A general relationship is derived for the abundance of an imperfect dendrimer with a given number of missing constitutional repeating units in the two outmost layers. The relationship is used in the interpretation of the MALDI TOF mass spectrum of the second-generation carbosilane dendrimer prepared by the iterative divergent method. The model quantitatively describes the spectrum of the dendrimer and correctly predicts the MALDI TOF mass spectrum of its first-generation precursor. Thus, the use of well-resolved MALDI TOF mass spectra for assessing the purity of low-generation dendrimers with uniform end groups is substantiated for carbosilane dendrimers and to lesser extent for dendrimers in general.
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