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Related Experiment Videos

Chloroquine induced pruritus--questionnaire based epidemiological study.

Adekunle O George1

  • 1Dermatology Unit, Department of Medicine, University College Hospital, Ibadan, Nigeria. adekunlegeorge2003@yahoo.com

African Journal of Health Sciences
|February 15, 2007
PubMed
Summary
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Chloroquine-induced pruritus (CP) is a common side effect in Nigerians, often lasting several days. Identifying a cheap antidote for CP is crucial for maintaining chloroquine

Area of Science:

  • Pharmacology
  • Epidemiology
  • Dermatology

Background:

  • Chloroquine (CQ) is a widely used medication for malaria, amoebiasis, and connective tissue diseases.
  • Chloroquine-induced pruritus (CP) is a significant side effect, particularly limiting its use in Black populations.
  • Understanding the epidemiology and clinical features of CP is essential for its management.

Purpose of the Study:

  • To investigate the factors and features associated with the development of chloroquine-induced pruritus (CP).
  • To determine the prevalence, duration, and affected body sites of CP in a Nigerian tertiary hospital.
  • To explore potential triggers and relieving factors for CP.

Main Methods:

  • A descriptive, cross-sectional, questionnaire-based epidemiological study.

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  • Involved medical and nursing students, doctors, and other healthcare workers with a history of CP.
  • Data collected on personal and familial history of CP, duration, intensity, affected sites, and relieving factors.

    • Main Results:

    • CP intensity was not reduced by lower chloroquine doses.
    • 92% of subjects had close relatives who experienced CP.
    • Itching typically lasted 1-3 days (84.5%), with generalized itching and involvement of hands, legs, and perineum being common.
    • Oral chloroquine caused itching in 100% of cases, while intramuscular injection caused itching in 49%.

    Conclusions:

    • Chloroquine-induced pruritus is a prevalent issue in Nigeria, with a strong familial predisposition.
    • The development of a cost-effective antidote for CP is urgently needed to ensure the continued utility of chloroquine in Nigeria and West Africa.
    • Further research into the mechanisms and management of CP is warranted.