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Growth and body composition in children with chronic kidney disease

R Rashid1, E Neill, H Maxwell

  • 1Bone & Endocrine Research Group, Royal Hospital for Sick Children, Yorkhill, Glasgow, G3 8SJ, UK.

The British Journal of Nutrition
|February 15, 2007
PubMed

Insights

Growth failure in children with chronic kidney disease stems from multiple factors, including nutrition and endocrine issues. Understanding these mechanisms and body composition is key to improving outcomes.

Area of Science:

  • Pediatric Nephrology
  • Growth and Development
  • Metabolic Disorders

Background:

  • Growth failure is a significant complication in childhood chronic kidney disease (CKD).
  • Multiple pathophysiological mechanisms contribute to impaired growth in pediatric CKD.
  • Nutritional deficits and endocrine dysfunction are frequently observed in these children.

Purpose of the Study:

  • To review the pathophysiological mechanisms of growth failure in pediatric CKD.
  • To emphasize the roles of nutritional problems and endocrine dysfunction.
  • To examine the impact of body composition on growth, nutrition, and long-term outcomes.

Main Methods:

  • Literature review focusing on growth failure in pediatric chronic kidney disease.
  • Analysis of pathophysiological mechanisms, nutritional status, and endocrine function.
  • Evaluation of body composition metrics (fat mass, lean mass) and their clinical relevance.

Main Results:

  • Growth failure in pediatric CKD is multifactorial, involving complex interactions.
  • Nutritional deficiencies and hormonal imbalances significantly impede growth.
  • Abnormalities in body composition are linked to poorer health outcomes.

Conclusions:

  • Addressing nutritional and endocrine issues is crucial for managing growth failure in pediatric CKD.
  • Body composition analysis provides valuable insights into disease progression and prognosis.
  • Further research on body composition may improve long-term morbidity and mortality in these patients.

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