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Caucasian genes in American blacks: new data
R Chakraborty1, M I Kamboh, M Nwankwo
1Center for Demographic and Population Genetics, University of Texas Graduate School of Biomedical Sciences, Houston 77225.
American Journal of Human Genetics
|January 1, 1992
Summary
This study estimates the proportion of Caucasian genes in U.S. Black individuals using 15 protein-coding genetic loci. The findings indicate approximately 25.2% Caucasian genetic admixture in the Pittsburgh Black population.
Area of Science:
- Population Genetics
- Human Genetics
- Forensic Science
Background:
- Genetic admixture is a significant factor in population diversity.
- Accurate estimation of admixture proportions is crucial for genetic studies.
Purpose of the Study:
- To estimate the proportion of Caucasian genes in U.S. Black individuals in Pittsburgh.
- To assess the utility of polymorphic protein-coding loci for admixture studies.
Main Methods:
- Analysis of allele frequencies at 15 polymorphic protein-coding loci.
- Comparison of allele frequencies between U.S. Black individuals, U.S. White individuals, and Nigerian samples.
- Utilizing unique genetic variants to estimate admixture.
Main Results:
- The proportion of Caucasian genes in Pittsburgh's U.S. Black population was estimated at 25.2% +/- 2.7%.
- Estimates derived from unique African variants (24.8% +/- 6.2%) were consistent with the overall pooled estimate.
- Homogeneity across locus-specific estimates suggests suitability for admixture studies.
Conclusions:
- The 15 polymorphic protein-coding loci provide a precise method for estimating Caucasian genetic admixture in U.S. Black populations.
- These loci, particularly those with unique African variants, are valuable for genetic-epidemiologic studies in admixed populations.
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