Related Experiment Video
Updated: Jul 17, 2026

Full-Endoscopic Surgery for Hypothalamic Hamartoma Resection
Published on: April 12, 2024
An extreme case of Heyde syndrome
Ivo Giovannini1, Carlo Chiarla, Marino Murazio
1Department of Surgery, Hepatobiliary Surgery Unit, Catholic University of Sacred Heart School of Medicine, Rome, Italy. ivo.giovannini@rm.unicatt.it
Background:
The Heyde syndrome consists of the association of gastrointestinal bleeding from angiodysplasia with aortic valve stenosis. Its existence has been repeatedly questioned or reconfirmed, and the proposed underlying mechanism is the degradation of a coagulation factor caused by the stenotic valve, which facilitates bleeding from angiodysplastic lesions.
Patient Case:
We report the case of a patient with severe recurrent small-intestinal bleeding from angiodysplasia, diagnosed by a videocapsule, and aortic valve stenosis. He underwent aortic valve replacement with a bioprosthesis as an extreme life-saving procedure. The operation was followed by the cessation of bleeding for 10 months, then bleeding recurred, emergency bowel resection was needed, and was followed by a chain of events which led to the patient's death.
Conclusion:
This case offers an extreme example of the challenging issues still involved in the management of patients with Heyde syndrome.
Related Concept Videos
Hyperosmolar Hyperglycemic State
Adrenal Gland Disorders
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Cushing Syndrome I: Introduction
Cushing Syndrome II: Pathophysiology
Huntington Disease l: Introduction
Cardiomyopathy III: Hypertrophic Cardiomyopathy