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[Iminosugars: current and future therapeutic applications].

O Martin1

  • 1ICOA, Cnrs & Université d'Orléans, BP 6759, F 45067 Orléans Cedex. Olivier.Martin@univ-orelans.fr

Annales Pharmaceutiques Francaises
|February 15, 2007
PubMed
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Iminosugars, a class of glycomimetics, are nitrogen-containing sugar analogs with diverse biological activities. These compounds are potent glycosidase inhibitors and have led to therapeutic agents for diabetes, lysosomal diseases, and are being investigated for cancer and viral infections.

Area of Science:

  • Carbohydrate Chemistry
  • Medicinal Chemistry
  • Glycobiology

Context:

  • Iminosugars are glycomimetics where the oxygen ring of monosaccharides is replaced by a nitrogen-containing ring.
  • First synthesized in 1966 and discovered in bacterial extracts, their potential as glycosidase inhibitors was recognized later.
  • Significant research has since uncovered their broad biological activities.

Purpose:

  • To explore the synthesis and biological properties of iminosugars.
  • To highlight their role as glycosidase inhibitors and their therapeutic potential.
  • To review their applications in treating various diseases.

Summary:

  • Iminosugars are nitrogen-containing sugar analogs with significant therapeutic potential.
  • They function as potent inhibitors of glycosidases, glycosyltransferases, and other enzymes.

Related Experiment Videos

  • Key examples include Miglitol for diabetes and N-butyl-1-deoxynojirimycin (Zavesca) for lysosomal storage diseases.

    • Impact:

    • Iminosugars have led to approved drugs for diabetes and Gaucher disease.
    • Ongoing research explores their use in treating cancers, Fabry disease, and viral infections like hepatitis B.
    • This class of compounds represents a promising area in drug discovery and development.