Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fleshing out filaggrin phenotypes.

Alan D Irvine1

  • 1Department of Pediatric Dermatology, Our Lady's Children's Hospital, Dublin, Ireland. irvinea@tcd.ie

The Journal of Investigative Dermatology
|February 15, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dupilumab treatment improves linear growth and bone biomarkers in children with atopic dermatitis: Post hoc analysis of a phase 3 randomized, placebo-controlled clinical trial and an open-label extension study.

Journal of the American Academy of Dermatology·2026
Same author

Author Correction: Atopic dermatitis.

Nature reviews. Disease primers·2026
Same author

Three-Year Efficacy and Safety of Lebrikizumab in Patients with Moderate-to-Severe Atopic Dermatitis: A Long-Term Extension (ADjoin).

Dermatology and therapy·2026
Same author

A Durability Index for Atopic Dermatitis: Indirect Comparison of Lebrikizumab, Dupilumab, and Tralokinumab in Maintaining Efficacy Under Variable Treatment Adherence.

Dermatology and therapy·2026
Same author

Atopic dermatitis.

Nature reviews. Disease primers·2026
Same author

Future directions in atopic dermatitis.

Journal of the American Academy of Dermatology·2026

Filaggrin null alleles are linked to eczema in European populations. This eczema may be more persistent and associated with asthma and palmar hyperlinearity.

Area of Science:

  • Genetics
  • Dermatology
  • Allergy

Background:

  • Filaggrin (FLG) null alleles are associated with eczema.
  • Replication of this association across European populations is crucial.
  • Understanding the specific eczema phenotype linked to FLG mutations is needed.

Purpose of the Study:

  • To confirm the association between filaggrin null alleles and eczema in European cohorts.
  • To investigate the phenotypic characteristics of FLG-associated eczema.
  • To explore potential links between FLG mutations, eczema persistence, asthma, and palmar hyperlinearity.

Main Methods:

  • Analysis of data from three large, well-conducted studies.
  • Observational and cohort study designs likely employed.
  • Phenotypic data collection on eczema characteristics, including persistence, palmar changes, and asthma comorbidity.

Related Experiment Videos

Main Results:

  • Confirmation of the association between filaggrin null alleles and eczema across European populations.
  • Early evidence suggests FLG-associated eczema exhibits increased persistence.
  • FLG-associated eczema shows a higher likelihood of palmar hyperlinearity and asthma comorbidity.

Conclusions:

  • The association between filaggrin null alleles and eczema is robustly replicated in European populations.
  • FLG-associated eczema presents with distinct phenotypic features, including persistence and palmar hyperlinearity.
  • Further cohort studies are warranted to confirm the association with asthma and refine understanding of FLG's role in eczema pathogenesis.