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Related Experiment Videos

Cell adhesion molecules: signalling functions at the synapse.

Matthew B Dalva1, Andrew C McClelland, Matthew S Kayser

  • 1University of Pennsylvania Medical Center, Department of Neuroscience, BRB II/III, Room 1114, 421 Curie Blvd., Philadelphia, Pennsylvania 19104, USA. dalva@mail.med.upenn.edu

Nature Reviews. Neuroscience
|February 15, 2007
PubMed
Summary

Cell adhesion molecules at synapses are crucial for neuronal development and function. These proteins guide synapse formation, maturation, and plasticity, impacting cell communication.

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Area of Science:

  • Neuroscience
  • Cell Biology
  • Molecular Biology

Background:

  • Cell adhesion molecules (CAMs) are prevalent at neuronal synapses.
  • These molecules link pre- and postsynaptic structures.
  • Their roles extend beyond mechanical connections.

Purpose of the Study:

  • To review the functions of synaptic adhesion proteins.
  • To discuss their roles during neural development and in mature synapses.

Main Methods:

  • Literature review of synaptic adhesion proteins.

Main Results:

  • Synaptic adhesion proteins are vital for synapse formation and maturation.
  • They play key roles in synaptic function and plasticity.

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  • These proteins are integral to trans-cellular communication at synapses.

    • Conclusions:

    • Synaptic adhesion proteins are essential for establishing and maintaining functional neural connections.
    • They are critical components of synaptic communication, complementing traditional neurotransmission.