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Updated: Jul 17, 2026

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes
Published on: June 13, 2014
Cell adhesion molecules: signalling functions at the synapse
Matthew B Dalva1, Andrew C McClelland, Matthew S Kayser
1University of Pennsylvania Medical Center, Department of Neuroscience, BRB II/III, Room 1114, 421 Curie Blvd., Philadelphia, Pennsylvania 19104, USA. dalva@mail.med.upenn.edu
Abstract:
Many cell adhesion molecules are localized at synaptic sites in neuronal axons and dendrites. These molecules bridge pre- and postsynaptic specializations but do far more than simply provide a mechanical link between cells. In this review, we will discuss the roles these proteins have during development and at mature synapses. Synaptic adhesion proteins participate in the formation, maturation, function and plasticity of synaptic connections. Together with conventional synaptic transmission mechanisms, these molecules are an important element in the trans-cellular communication mediated by synapses.
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