Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Compositae dermatitis from airborne parthenolide.

E Paulsen1, L P Christensen, K E Andersen

  • 1Department of Dermatology, Odense University Hospital, DK-5000 Odense C, Denmark. evy.paulsen@ouh.fyns-amt.dk

The British Journal of Dermatology
|February 16, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Risk of Rewilding.

Contact dermatitis·2025
Same author

The epidemic of methylisothiazolinone contact allergy in Europe: follow-up on changing exposures.

Journal of the European Academy of Dermatology and Venereology : JEADV·2019
Same author

Sociodemographic factors do not have a large influence on adherence to topical treatment in patients with psoriasis.

The British journal of dermatology·2019
Same author

Use of topical antipsoriatic drugs in Denmark: a nationwide drug utilization study.

The British journal of dermatology·2018
Same author

A smartphone application supporting patients with psoriasis improves adherence to topical treatment: a randomized controlled trial.

The British journal of dermatology·2018
Same author

The effect of poly (lactic-co-glycolic) acid composition on the mechanical properties of electrospun fibrous mats.

International journal of pharmaceutics·2017

Feverfew allergy can be airborne, with parthenolide (PHL) identified as the primary allergen. This study confirms airborne particles from feverfew cause allergic reactions in sensitive patients.

Area of Science:

  • Dermatology
  • Allergology
  • Plant Chemistry

Background:

  • Airborne Compositae dermatitis is suspected but lacks definitive proof.
  • Feverfew (Tanacetum parthenium) is a suspected cause of airborne allergy.
  • Parthenolide (PHL) is the key sesquiterpene lactone (SQL) allergen in feverfew.

Purpose of the Study:

  • To assess feverfew-derived monoterpenes and sesquiterpenes' allergenicity in allergic patients.
  • To confirm the role of PHL and other SQLs in airborne contact allergy.

Main Methods:

  • Patch testing feverfew-allergic patients with plant extracts and airborne particle samples.
  • Utilizing high-volume air sampler (HIVAS) and headspace techniques for particle collection.
  • Gas chromatography-mass spectrometry (GC-MS) for allergen identification and quantification.

Related Experiment Videos

Main Results:

  • Eight of 12 feverfew-allergic patients reacted to HIVAS filter extract.
  • PHL was detected in allergenic concentrations (510 ng mL(-1)) in the HIVAS extract.
  • Positive reactions to PHL were observed down to 8.1 ng; no reactions to monoterpenes or sesquiterpenes.

Conclusions:

  • Clinical evidence confirms feverfew-allergic patients are sensitive to airborne plant particles.
  • Isolation of PHL in allergenic amounts strongly implicates it as the causative agent.
  • This study provides proof for airborne contact allergy to feverfew mediated by PHL.