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Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
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Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
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Skin Cancer01:30

Skin Cancer

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Related Experiment Video

Updated: Jul 17, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Paraneoplastic pemphigus without an underlying neoplasm.

G T Park1, J H Lee, S J Yun

  • 1Department of Dermatology, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea.

The British Journal of Dermatology
|February 16, 2007
PubMed
Summary

This study details a paraneoplastic pemphigus (PNP) case in a 52-year-old man, diagnosed via immunopathology, who showed no underlying neoplasm over 8 years. The chronic skin eruption persisted despite extensive cancer screening, highlighting a rare presentation of PNP.

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Granulocyte-dependent Autoantibody-induced Skin Blistering
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Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
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Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid

Published on: June 17, 2025

Area of Science:

  • Dermatology
  • Immunology
  • Oncology

Background:

  • Paraneoplastic pemphigus (PNP) is a rare autoimmune blistering disease often associated with an underlying neoplasm.
  • Early diagnosis and identification of the associated malignancy are crucial for patient management.

Observation:

  • A 52-year-old male presented with a 7-year history of a chronic, relapsing vesiculobullous eruption on the face and trunk.
  • The eruption was characterized by scattered flaccid vesicles with crusts that fluctuated in severity.

Findings:

  • Immunopathological criteria, including histopathology, immunoblotting, and immunoprecipitation, confirmed the diagnosis of PNP.
  • Extensive investigations over an 8-year follow-up, including imaging (PET/CT, ultrasound) and laboratory tests, failed to detect any evidence of an underlying neoplasm.
  • This case represents a rare instance of PNP without an identifiable malignancy during a prolonged observation period.

Implications:

  • This case challenges the typical association of PNP with malignancy, suggesting PNP can occur without detectable cancer.
  • Highlights the importance of considering PNP even in the absence of a clear neoplastic trigger.
  • Further research is needed to understand the pathogenesis of idiopathic PNP and its long-term management.