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Related Experiment Video

Updated: Jul 17, 2026

Establishing a Porcine Ex Vivo Cornea Model for Studying Drug Treatments against Bacterial Keratitis
09:22

Establishing a Porcine Ex Vivo Cornea Model for Studying Drug Treatments against Bacterial Keratitis

Published on: May 12, 2020

Infectious bovine keratoconjunctivitis antimicrobial therapy.

C S McConnel1, L Shum, J K House

  • 1University of Sydney, Faculty of Veterinary Science, Camden, NSW 2570.

Australian Veterinary Journal
|February 16, 2007
PubMed
Summary

Infectious bovine keratoconjunctivitis (IBK) treatment success in cattle depends on effective antimicrobial selection and delivery. Understanding drug distribution and sensitivity is key to preventing ulcer recurrence and economic loss.

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Area of Science:

  • Veterinary Ophthalmology
  • Bovine Infectious Diseases
  • Antimicrobial Therapy

Background:

  • Infectious bovine keratoconjunctivitis (IBK) is a prevalent and economically significant cattle disease.
  • Moraxella bovis is the primary cause of IBK, leading to corneal ulcers.
  • Ulcer recurrence can occur if treatment fails, impacting cattle health and farm economics.

Purpose of the Study:

  • To review antimicrobial drug delivery methods for IBK.
  • To highlight the importance of antimicrobial sensitivity and distribution in ocular tissues and tears for effective treatment.
  • To inform antimicrobial therapy recommendations for Australian IBK outbreaks.

Main Methods:

  • Literature review of antimicrobial pharmacokinetics and pharmacodynamics in cattle eyes.
  • Analysis of drug delivery routes: subconjunctival injection, topical application, and systemic administration.
  • Consideration of factors influencing practical antimicrobial delivery in different farming systems.

Main Results:

  • Successful elimination of Moraxella bovis leads to consistent corneal ulcer healing rates.
  • Treatment failure can result in ulcer reoccurrence.
  • Antimicrobial efficacy is influenced by drug delivery frequency and mode.

Conclusions:

  • Appropriate antimicrobial selection for IBK requires knowledge of sensitivity and ocular distribution.
  • Practical antimicrobial delivery methods vary based on farm management intensity.
  • Recommendations for Australian IBK outbreaks must integrate pharmacokinetic data, regulations, and costs.