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Bilateral angle closure glaucoma induced by sulphonamide-derived medications
Grace C Lee1, Christina P Tam, Helen V Danesh-Meyer
1Wills Eye Hospital, Thomas Jefferson Medical School, Philadelphia, PA, USA.
Clinical & Experimental Ophthalmology
|February 16, 2007
Summary
Sulphonamide-derived medications can cause bilateral angle closure glaucoma. Early diagnosis and drug cessation are crucial for managing this adverse effect.
Area of Science:
- Ophthalmology
- Pharmacology
Background:
- Sulphonamide-derived medications are common but often unrecognized triggers for ocular side effects.
- Angle closure glaucoma is a potential, serious adverse event associated with these drugs.
Observation:
- Three cases of bilateral angle closure glaucoma induced by sulphonamide-derived medications (sulfasalazine, acetazolamide, hydrochlorothiazide) were reviewed.
- Patients presented with persistent elevated intraocular pressure, even after iridotomy.
Findings:
- The mechanism involves an idiosyncratic reaction in uveal tissues, leading to ciliary body and choroid expansion.
- Cessation of the suspected sulphonamide-derived medication is essential for reversing the condition.
Implications:
- Prompt identification of sulphonamide-derived medications is critical for diagnosis and management.
- Diagnostic tools like refraction and ultrasound biomicroscopy can aid in confirming the diagnosis.
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