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Cushing syndrome from percutaneous absorption of 1% hydrocortisone ointment in Netherton syndrome
Caroline P Halverstam1, Akshaya Vachharajani, Susan Bayliss Mallory
1Departments of Internal Medicine (Dermatology) and Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.
Abstract:
Netherton syndrome is a congenital skin disease associated with decreased skin barrier function and increased percutaneous absorption. We report an 11-year-old boy with Netherton syndrome who developed Cushing syndrome after application of 1% hydrocortisone ointment to his entire body for more than 1 year. This presentation illustrates that even low-potency steroid ointments should be used with caution in Netherton syndrome and warns about the use of long-term topical medications with potential systemic side effects when used in large quantities in any chronic skin disease.
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