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Tissue-driven hypothesis of genomic evolution and sequence-expression correlations.

Xun Gu1, Zhixi Su

  • 1School of Life Sciences, Institutes of Biomedical Sciences, Center for Evolutionary Biology, Fudan University, Shanghai 200433, China. xgu@iastate.edu

Proceedings of the National Academy of Sciences of the United States of America
|February 16, 2007
PubMed
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Tissue constraints influence gene evolution, showing that expression and sequence divergence correlate across species and paralogs. Genes in stringent tissues evolve slower, supporting a tissue-driven hypothesis for genomic evolution.

Area of Science:

  • Genomics
  • Evolutionary Biology
  • Molecular Biology

Background:

  • Different tissues possess unique developmental constraints impacting gene expression.
  • These constraints lead to varying evolutionary tolerance for genomic changes across tissues.

Purpose of the Study:

  • To propose and test the "tissue-driven hypothesis" for genomic evolution.
  • To investigate the relationship between tissue expression divergence and sequence divergence.
  • To explore how tissue-specific constraints affect gene evolution rates.

Main Methods:

  • Formulated the "tissue-driven hypothesis" based on the stabilizing selection model.
  • Analyzed human-mouse microarray data to test predicted genomic correlations.
  • Examined covariation between tissue expression distance (E(ti)) and tissue sequence distance (D(ti)).

Related Experiment Videos

  • Investigated the correlation between interspecies expression divergence and paralogous gene duplicate tissue distance (T(dup)).

    • Main Results:

    • A significant correlation was found between E(ti) and D(ti) when expression and protein sequence divergence share tissue constraints.
    • The tissue-driven hypothesis explained the correlation between interspecies expression divergence and T(dup).
    • Genes in stringent tissues (e.g., neurorelated) evolve slower than those in relaxed tissues (e.g., hormone-related) for similar expression breadth.

    Conclusions:

    • Tissue factors are crucial in shaping genomic evolution patterns and correlations.
    • The "tissue-driven hypothesis" provides a framework for understanding tissue-specific evolutionary dynamics.
    • Genomic evolution is influenced by the interplay between tissue constraints and gene expression divergence.