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Related Experiment Videos

Cannabinoid action in the olfactory epithelium.

Dirk Czesnik1, Detlev Schild, Josko Kuduz

  • 1Department of Neurophysiology and Cellular Biophysics and Deutsche Forschungsgemeinschaft Research Center for Molecular Physiology of the Brain, University of Göttingen, Humboldtallee 23, 37073 Göttingen, Germany. dczesni@gwdg.de

Proceedings of the National Academy of Sciences of the United States of America
|February 16, 2007
PubMed
Summary

The cannabinergic system significantly impacts how tadpoles process odors at the olfactory epithelium level. Cannabinoid receptor 1 (CB1) antagonists alter odor responses in olfactory neurons.

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Area of Science:

  • Neuroscience
  • Olfactory receptor neuron function
  • Cannabinoid system

Background:

  • Neuromodulators influence odor perception.
  • Evidence suggests modulation occurs within the olfactory epithelium.
  • Cannabinergic system's role in peripheral olfaction is under investigation.

Purpose of the Study:

  • To investigate cannabinergic actions in the olfactory epithelium of Xenopus laevis tadpoles.
  • To determine the effect of CB1 receptor antagonists on olfactory receptor neurons.
  • To elucidate the functional impact of the cannabinergic system on peripheral odor processing.

Main Methods:

  • Application of CB1 receptor-specific antagonists (AM251, AM281, LY320135).
  • Measurement of odor-evoked calcium changes in olfactory receptor neurons.

Related Experiment Videos

  • Localization of CB1-like immunoreactivity using immunohistochemistry.
  • Recording of odor-induced spike-associated currents in individual olfactory receptor neurons.

    • Main Results:

    • CB1 receptor antagonists modulated odor-evoked calcium changes in olfactory receptor neurons.
    • CB1-like immunoreactivity was detected on the dendrites of olfactory receptor neurons.
    • Cannabinergic system influenced odor-induced spike-associated currents in olfactory receptor neurons.

    Conclusions:

    • The cannabinergic system profoundly impacts peripheral odor processing in Xenopus laevis tadpoles.
    • CB1 receptors are present and functional in the olfactory epithelium.
    • Cannabinergic modulation likely plays a significant role in regulating olfactory sensory input.