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Related Experiment Video

Updated: Jul 16, 2026

Investigating Migraine-Like Behavior Using Light Aversion in Mice

Investigating Migraine-Like Behavior Using Light Aversion in Mice

Published on: August 11, 2021

A Correlation between Migraine, Histamine and Immunoglobulin E.

Parisa Gazerani¹, Zahra Pourpak, A Ahmadiani

¹Department of Neuroscience Research Center, Shaheed Beheshri University of Medical Sciences, Tehran, Iran.

Iranian Journal of Allergy, Asthma, and Immunology

|February 16, 2007

Summary

Elevated immunoglobulin E (IgE) and histamine levels suggest a link between allergies and migraine. Managing allergies may help prevent or treat migraine attacks.

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Published on: July 29, 2021

Area of Science:

Neurology
Immunology
Allergology

Background:

Migraine pathophysiology remains largely unknown, despite affecting 15% of the population.
The role of allergy, specifically IgE-mediated mechanisms and histamine, in migraine is controversial.

Purpose of the Study:

To evaluate serum total IgE and histamine levels in migraine patients.
To investigate the influence of allergy on these levels in migraine.

Main Methods:

Serum samples collected from 70 migraine patients (with and without allergy history) and 45 controls.
Measurements of total IgE and histamine levels using ELISA and fluorimetric methods, respectively.
Samples analyzed during both attack and remission periods.

Main Results:

Significantly higher total IgE levels in migraine patients with allergy compared to controls and migraine patients without allergy (P<0.0001).
Significantly elevated plasma histamine levels in migraine patients (with and without allergy) during both headache and symptom-free periods compared to controls (P<0.0001).

Conclusions:

An IgE-mediated mechanism may influence migraine, particularly in allergic individuals.
Histamine plays a significant role in migraine, independent of allergic conditions.
Allergy avoidance could be a beneficial strategy for migraine prophylaxis and treatment.