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Cronkhite-Canada syndrome associated with schizophrenia
Masaharu Nakayama1, Hiromi Muta, Shinichi Somada
1Department of Advanced Molecular and Cell Therapy, Kyushu University Hospital, Fukuoka, Japan.
Internal Medicine (Tokyo, Japan)
|February 16, 2007
Summary
This study details a rare case of Cronkhite-Canada syndrome in a patient with schizophrenia. The patient experienced gastrointestinal polyposis and skin/nail changes, which improved with treatment.
Area of Science:
- Gastroenterology
- Psychiatry
- Dermatology
Background:
- Cronkhite-Canada syndrome (CCS) is a rare non-neoplastic gastrointestinal polyposis disorder.
- Schizophrenia is a chronic mental health condition with complex pathophysiology.
- Co-occurrence of CCS and schizophrenia is exceptionally rare, with no prior reports.
Observation:
- A 64-year-old male with a 30-year history of schizophrenia presented with alopecia, nail atrophy, skin hyperpigmentation, and gastrointestinal polyposis.
- Endoscopic ultrasonography revealed diffuse mucosal thickening and edema in the stomach and colon.
- Symptoms included hair loss, nail abnormalities, skin discoloration, and inflammatory polyps.
Findings:
- The patient was diagnosed with Cronkhite-Canada syndrome.
- Treatment involved parenteral hyperalimentation and tranexamic acid.
- Significant improvement in physical findings and polyposis was observed post-treatment.
Implications:
- This case highlights a potential, previously unreported association between schizophrenia and Cronkhite-Canada syndrome.
- Further research may explore shared etiological factors or pathomechanisms.
- Clinicians should consider CCS in schizophrenic patients presenting with relevant gastrointestinal and dermatological symptoms.
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