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Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

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Related Experiment Video

Updated: Jul 16, 2026

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas
09:21

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

Published on: September 13, 2019

[Rhabdomyosarcoma].

Hajime Hosoi1, Kunihiko Tsuchiya, Tohru Sugimoto

  • 1Dept. of Pediatrics, Kyoto Prefectural University of Medicine.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|February 16, 2007
PubMed
Summary

Childhood rhabdomyosarcoma (RMS) survival rates in Japan lag behind Western countries. The newly established Japan Rhabdomyosarcoma Study Group (JRSG) aims to improve outcomes through dedicated research and standardized multimodal therapy.

Area of Science:

  • Pediatric Oncology
  • Soft Tissue Sarcomas
  • Cancer Genetics

Context:

  • Rhabdomyosarcoma (RMS) is the most prevalent soft-tissue sarcoma in pediatric patients.
  • Significant survival improvements (25% to >70%) observed in Europe/US since 1970 due to multimodal therapy and cooperative trials.
  • Multimodal therapy for RMS includes surgery, molecularly-guided diagnosis, chemotherapy, and radiotherapy based on risk stratification.

Purpose:

  • To address the disparity in RMS survival rates between Japan and Western countries.
  • To establish a nationwide study and standardized treatment protocols for pediatric RMS in Japan.
  • To improve the overall survival and treatment outcomes for Japanese children diagnosed with rhabdomyosarcoma.

Summary:

  • Japanese RMS patient survival rates are lower than in the US/Europe across all risk groups.

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Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model
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Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

Published on: January 13, 2023

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Last Updated: Jul 16, 2026

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas
09:21

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

Published on: September 13, 2019

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model
13:41

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

Published on: January 13, 2023

  • Nationwide RMS studies have not been conducted in Japan previously.
  • The Japan Rhabdomyosarcoma Study Group (JRSG) has been formed to conduct studies and establish standard therapies.

    • Impact:

    • Establishment of the Japan Rhabdomyosarcoma Study Group (JRSG) to facilitate research.
    • Development of optimized, risk-stratified multimodal treatment protocols for Japanese pediatric RMS patients.
    • Potential to significantly enhance survival rates and quality of life for children with RMS in Japan.