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Updated: Jul 16, 2026

Conformational Evaluation of HIV-1 Trimeric Envelope Glycoproteins Using a Cell-based ELISA Assay
Published on: September 14, 2014
A functional human IgM response to HIV-1 Env after immunization with NYVAC HIV C
Neil C Sheppard1, Anna C Bates, Quentin J Sattentau
1Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.
Abstract:
Env-specific IgG and IgM were detected in 25 and 60%, respectively, of volunteers immunized with NYVAC expressing clade C gp120. The serum sample with the highest IgM titre but undetectable IgG neutralized the homologous isolate with a reciprocal IC90 titre of 7.8 in the absence of complement, and 24.4 in the presence of complement (P = 0.0003). These results suggest that vaccine-induced, Env-specific IgM may have antiviral activity and should be subjected to further investigation.
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