Probing cellular systems with chemistry

Same author

Selective and Potent Peptide Binders of RNF43 for Wnt Signaling Inhibition.

ACS central science·2025

Same author

Reconstitution of the alternative pathway of the complement system enables rapid delineation of the mechanism of action of novel inhibitors.

The Journal of biological chemistry·2024

Same author

Cystine-knot peptide inhibitors of HTRA1 bind to a cryptic pocket within the active site region.

Nature communications·2024

Same author

A phage-displayed disulfide constrained peptide discovery platform yields novel human plasma protein binders.

PloS one·2024

Same author

Disulfide-constrained peptide scaffolds enable a robust peptide-therapeutic discovery platform.

PloS one·2024

Same author

Potent and selective binders of the E3 ubiquitin ligase ZNRF3 stimulate Wnt signaling and intestinal organoid growth.

Cell chemical biology·2023

Same journal

Allosteric disordering of eIF2B regulates the integrated stress response.

Nature chemical biology·2026

Same journal

A tail of two ligases.

Nature chemical biology·2026

Same journal

Non-canonical cytochrome P450 enzymes expand the diversity of bacterial hemoproteins.

Nature chemical biology·2026

Same journal

Image-guided activation of drugs with electromagnetic radiation.

Nature chemical biology·2026

Same journal

Detecting protein fluctuations at scale.

Nature chemical biology·2026

Same journal

Revealing the Wnt signalosome.

Nature chemical biology·2026

Related Experiment Videos

Probing cellular systems with chemistry

Related Concept Videos

Selective and Potent Peptide Binders of RNF43 for Wnt Signaling Inhibition.

Reconstitution of the alternative pathway of the complement system enables rapid delineation of the mechanism of action of novel inhibitors.

Cystine-knot peptide inhibitors of HTRA1 bind to a cryptic pocket within the active site region.

A phage-displayed disulfide constrained peptide discovery platform yields novel human plasma protein binders.

Disulfide-constrained peptide scaffolds enable a robust peptide-therapeutic discovery platform.

Potent and selective binders of the E3 ubiquitin ligase ZNRF3 stimulate Wnt signaling and intestinal organoid growth.

Allosteric disordering of eIF2B regulates the integrated stress response.

A tail of two ligases.

Non-canonical cytochrome P450 enzymes expand the diversity of bacterial hemoproteins.

Image-guided activation of drugs with electromagnetic radiation.

Detecting protein fluctuations at scale.

Revealing the Wnt signalosome.

Related Experiment Videos

Probing cellular systems with chemistry

Related Concept Videos

Related Articles

Selective and Potent Peptide Binders of RNF43 for Wnt Signaling Inhibition.

Reconstitution of the alternative pathway of the complement system enables rapid delineation of the mechanism of action of novel inhibitors.

Cystine-knot peptide inhibitors of HTRA1 bind to a cryptic pocket within the active site region.

A phage-displayed disulfide constrained peptide discovery platform yields novel human plasma protein binders.

Disulfide-constrained peptide scaffolds enable a robust peptide-therapeutic discovery platform.

Potent and selective binders of the E3 ubiquitin ligase ZNRF3 stimulate Wnt signaling and intestinal organoid growth.

Allosteric disordering of eIF2B regulates the integrated stress response.

A tail of two ligases.

Non-canonical cytochrome P450 enzymes expand the diversity of bacterial hemoproteins.

Image-guided activation of drugs with electromagnetic radiation.

Detecting protein fluctuations at scale.

Revealing the Wnt signalosome.