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A Mouse Model of in Utero Transplantation
Published on: January 27, 2011
Tumorigenicity of mouse-human diploid hybrids in nude mice
Science (New York, N.Y.)
|December 19, 1975
Abstract:
Somatic cell hybrids between normal mouse cells and simian virus 40 (SV40)-transformed human cells, which contained a diploid complement of mouse chromosomes and the human chromosome 7 carrying the genome of SV40, were tumorigenic in nude mice. One single copy of human chromosome 7 per hybrid cell appeared to be sufficient for the tumorigenicity of the hybrids.
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