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Intracranial Pharmacotherapy and Pain Assays in Rodents
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[Intranasal opioids for acute pain].

C Añez Simón1, M Rull Bartomeu, A Rodríguez Pérez

  • 1Servicio de Anestesiología, Reanimación y Terapéutica del Dolor y M. Paliativa, Hospital Universitario de Tarragona Joan XXIII, Tarragona. cristobal_anez@yahoo.es

Revista Espanola De Anestesiologia Y Reanimacion
|February 17, 2007
PubMed
Summary

Intranasal drug delivery offers a noninvasive route for pain management, bypassing liver metabolism. This review examines opioids like fentanyl for acute pain, noting similar side effects to IV routes.

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Area of Science:

  • Pharmacology
  • Drug Delivery Systems
  • Pain Management

Context:

  • Intranasal drug administration presents a noninvasive, well-tolerated transmucosal route.
  • The nasal mucosa offers a large, vascularized surface area for drug absorption.
  • Mucociliary clearance and physiological factors influence drug contact time and absorption.

Purpose:

  • To review the literature on intranasal administration of specific opioids for acute pain.
  • To evaluate the efficacy and safety of intranasal opioids compared to intravenous administration.

Summary:

  • Opioids including fentanyl, meperidine, diamorphine, and butorphanol were reviewed for intranasal administration in acute pain.
  • Adverse systemic effects mirror those of intravenous administration, commonly including drowsiness, nausea, and vomiting.
  • Local adverse effects such as a burning sensation and bad taste were also reported.

Impact:

  • Intranasal opioid administration is a viable alternative for managing acute pain.
  • Understanding absorption dynamics and potential side effects is crucial for clinical application.
  • This route may offer advantages in specific patient populations or clinical scenarios.