Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Myocardial reporter gene expression imaging].

Masayuki Inubushi1, Keiichiro Yoshinaga, Koichi Morita

  • 1Department of Molecular Imaging, Hokkaido University Graduate School of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|February 17, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Spatial and temporal tracking of multi-layered cells sheet using reporter gene imaging with human sodium iodide symporter: a preclinical study using a rat model of myocardial infarction.

European journal of nuclear medicine and molecular imaging·2024
Same author

Predictive Value of PERCIST for Locally Advanced Non-Small Cell Lung Cancer Treated with Preoperative Induction Therapy - A Multicenter Study in Japan.

Cancer management and research·2024
Same author

A Luciferase Reporter Assay to Detect Cellular Hypoxia In Vitro.

Methods in molecular biology (Clifton, N.J.)·2024
Same author

Radionuclide Reporter Imaging to Visualize Tumor Hypoxia Ex Vivo and In Vivo.

Methods in molecular biology (Clifton, N.J.)·2024
Same author

Spinal Instability as a Prognostic Factor in Patients With Spinal Metastasis of Castration-resistant Prostate Cancer.

Cancer diagnosis & prognosis·2023
Same author

[Impact of Residual Radioactivity Rate of <sup>99m</sup>Tc-macro Aggregated Albumin (MAA) in Syringes and Administration Routes with a Focus on Pediatric Nuclear Medicine Examinations].

Nihon Hoshasen Gijutsu Gakkai zasshi·2023

Radionuclide gene expression imaging uses reporter genes to track transcription activity noninvasively. Its cardiac applications have shifted from gene therapy to stem cell tracking.

Area of Science:

  • Molecular Imaging
  • Nuclear Medicine
  • Biotechnology

Context:

  • Cardiac radionuclide gene expression imaging initially targeted angiogenic gene therapy.
  • Applications have evolved towards stem/progenitor cell tracking due to clinical trial outcomes and vector risks.

Purpose:

  • To provide an overview of cardiac radionuclide gene expression imaging.
  • To discuss reporter gene/probe combinations and current cardiac gene therapy status.
  • To highlight applications in cell tracking.

Summary:

  • Radionuclide gene expression imaging visualizes gene transcription noninvasively using reporter genes and radioactive probes.
  • The technique's focus in cardiology has shifted from gene therapy monitoring to cell tracking in regenerative medicine.

Related Experiment Videos

  • This review covers principles, reporter systems, and cell tracking applications.

    • Impact:

    • Facilitates noninvasive monitoring of gene activity in cardiac research.
    • Enables tracking of transplanted cells in cardiac regenerative therapies.
    • Offers insights into the evolving role of molecular imaging in cardiovascular medicine.