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Upregulation of Mark3 and Rpgrip1 mRNA expression by jujuboside A in mouse hippocampus
Cheng Wang1, Zi-Li You, Qing Xia
1School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China.
Aim:
To investigate the effect of jujuboside A (JuA) on modulating gene expression in the hippocampus.
Methods:
The spontaneous activity of mice was monitored, and the differential display polymerase chain reaction was adapted to screen differentially-expressed genes modulated by JuA in the mouse hippocampus.
Results:
JuA significantly decreased the total activity intensity (P<0.01 vs control) at a dosage of 80 mg/kg, and the genes MAP/microtubule affinity-regulating kinase3 (Mark3) and retinitis pigmentosa GTPase regulator interacting protein1 (Rpgrip1) were upregulated by JuA in the mouse hippocampus.
Conclusion:
JuA had an inhibitory effect on the spontaneous activity of the mice, and JuA regulated the transcription of Mark3 and Rpgrip1 in the mouse hippocampus.
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