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Published on: August 2, 2017
The secretory endometrial protein, placental protein 14, in women with ectopic gestation
S Ruge1, S Sørensen, M Vejtorp
1Department of Obstetrics and Gynaecology, Hvidovre University Hospital, Copenhagen, Denmark.
Objective:
To determine the serum level of the secretory endometrial protein, placental protein 14 (PP14) and progesterone (P) in women with ectopic gestation.
Design:
Blood samples were collected prospectively and preoperatively. Reference range was determined from a prospective population of 98 women with uncomplicated pregnancies and normal outcome.
Setting:
The women were admitted to a university hospital.
Patients:
Fifty-nine women with laparoscopically verified ectopic pregnancy entered the study.
Intervention:
At the time of diagnosis PP14 and P were measured.
Main Outcome Measure:
After observing the low serum levels of PP14 and P, a correlation analysis was made and compared with the findings in normally pregnant women.
Results:
A significant positive correlation was found between the level of PP14 and P (P less than 0.00002), not found in normal intrauterine pregnancies.
Conclusions:
These findings suggest that the regulation of the PP14 production involves either a control mechanism from the ovary or is mediated by paracrine secretion.
