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Updated: Jul 16, 2026
Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting
Published on: November 30, 2015
Baseline level of platelet-leukocyte aggregates, platelet CD63 expression, and soluble P-selectin concentration in
Andelko Vidović1, Maja Vilibić, Alemka Markotić
1Department for Cellular Immunology, Institute of Immunology, Rockefellerova 10, HR-10 000 Zagreb, Croatia. avidovic@imz.hr
Abstract:
Platelets may have an important role in the development of cardiovascular disease (CVD) as a result of chronic stress. We conducted a pilot study to evaluate the effect of posttraumatic stress disorder (PTSD) on baseline platelet activation. Platelet-leukocyte aggregates (PLA) and CD63 expression were measured by flow cytometry, and soluble (s)P-selectin concentration was determined in sera of 20 Croatian male combat veterans with PTSD and 20 healthy civilians. Groups were matched in sex, age, body mass index (BMI) and traditional CVD risk factors. Our data showed no differences in measured parameters. Other platelet activation markers should be determined and a larger sample size used in future studies.
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