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Related Experiment Video

Updated: Jul 16, 2026

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
13:19

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

Molecular markers for prostate cancer.

Mark A Reynolds1, Kumar Kastury, Jack Groskopf

  • 1Gen-Probe Incorporated, 10210 Genetic Center Drive, San Diego, CA 92121, USA. markr@gen-probe.com

Cancer Letters
|February 17, 2007
PubMed
Summary

Prostate cancer diagnosis relies on PSA tests, but these lack specificity. New genomic assays targeting DNA/RNA in blood and urine show promise for more accurate prostate cancer detection.

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Area of Science:

  • Urology
  • Oncology
  • Genomics

Background:

  • Serum prostate-specific antigen (PSA) testing is a long-standing tool for prostate cancer diagnosis and management.
  • PSA testing exhibits limited specificity, with elevated levels observed in conditions like prostatitis and benign prostatic hyperplasia.
  • Previous alternative biomarkers also faced specificity challenges, necessitating novel diagnostic approaches.

Purpose of the Study:

  • To review recent advancements in molecular assays for prostate cancer detection.
  • To explore the potential of genomic biomarkers for improved prostate cancer diagnosis and prognosis.
  • To highlight the shift towards noninvasive specimen analysis, such as blood and urine, for prostate cancer assessment.

Main Methods:

  • Review of current research utilizing modern genomics technologies for biomarker discovery.

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miRNA Expression Analyses in Prostate Cancer Clinical Tissues

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MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR (qPCR)
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MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR (qPCR)

Published on: May 16, 2012

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Last Updated: Jul 16, 2026

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
13:19

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR (qPCR)
08:30

MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR (qPCR)

Published on: May 16, 2012

  • Investigation of molecular assays targeting DNA or RNA for prostate disease.
  • Focus on retrospective studies using microdissected prostatectomy tissue.
  • Exploration of applying genomic assays to noninvasive specimens like blood and urine.

    • Main Results:

    • Discovery of various molecular biomarkers with potential for specific correlation with prostate cancer.
    • Identification of limitations in traditional serum protein analytes due to lack of specificity.
    • Emerging progress in developing noninvasive genomic assays for prostate cancer.

    Conclusions:

    • Genomic assays hold significant promise for improving the specificity and accuracy of prostate cancer diagnosis.
    • The development of noninvasive molecular tests using blood or urine represents a key future direction.
    • Further research is needed to validate these novel biomarkers for clinical application.