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T-cell potential and development in vitro: the OP9-DL1 approach

Renée de Pooter1, Juan Carlos Zúñiga-Pflücker

  • 1Department of Immunology, University of Toronto, Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, ON M4N 3M5, Canada.

Current Opinion in Immunology
|February 17, 2007
PubMed

In vivo, T cells develop in the thymus from bone marrow-derived hematopoietic progenitors. Similarly, T cells can develop in vitro in model systems that mimic thymic function. The recent development of the OP9-DL1 cell culture system, a two-dimensional T-inductive environment, has provided greater access to the processes of commitment and development in T lymphocytes.

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