Related Experiment Video
Updated: Jul 16, 2026

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
Published on: March 17, 2016
Endocrine effects of breast cancer treatment
1Abramson Cancer Center of the University of Pennsylvania, PA, USA. carrie.stricker@uphs.upenn.edu
Objectives:
To discuss long-term physical effects of treatment for breast cancer including effects on reproductive, bone, sexual health, and related women's issues.
Data Sources:
Research articles, abstracts, literature reviews.
Conclusion:
Long-term effects of treatment have become increasingly prevalent in breast cancer survivors. The most common are effects on reproductive, bone, and sexual health.
Implications For Nursing Practice:
Long-term effects of treatment can have a significant negative impact on the long-term health and QOL of women with breast cancer. Oncology nurses are well-positioned to anticipate and address the reproductive and endocrine consequences of breast cancer treatment.
Related Concept Videos
Psychoneuroimmunology: Diabetes and Cancer
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Mitogens and the Cell Cycle
Target Cell Response to Hormones
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
Major Hormones and Their Functions
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and lactation.
Disorders of the Female Reproductive System

