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Published on: February 4, 2016
Chronic epidural motor cortical stimulation for movement disorders
Alberto Priori1, Jean-Pascal Lefaucheur
1Department of Neurological Sciences, University of Milan Medical School, Fondazione IRCCS Ospedale Maggiore Policlinico, Milan, Italy. alberto.priori@unimi.it
The Lancet. Neurology
|February 17, 2007
Summary
Epidural chronic motor cortical stimulation shows promise for improving movement disorders due to its safety and potential mechanisms. Further controlled studies are needed to confirm its therapeutic effects in conditions like Parkinson's disease.
Area of Science:
- Neuroscience
- Neurology
- Neurosurgery
Background:
- Recent data indicate epidural chronic motor cortical stimulation (CMCS) may improve movement disorders.
- The procedure is considered safe, suggesting potential as a therapeutic option.
Purpose of the Study:
- To discuss the rationale and physiological mechanisms behind CMCS for movement disorders.
- To highlight factors supporting CMCS, including motor cortex location and effects of cortical lesions.
Main Methods:
- Review of existing data and literature on cortical stimulation for movement disorders.
- Discussion of functional imaging findings and effects of transcranial magnetic stimulation.
Main Results:
- Several factors support CMCS, including motor cortex strategic position and observed improvements in some motor disorders post-lesion.
- Repetitive transcranial magnetic stimulation has shown benefits in Parkinson's disease and dystonia.
Conclusions:
- CMCS may be a valuable therapeutic option for movement disorders, pending controlled studies.
- The primary mechanism likely involves CMCS inducing bilateral changes via interconnected cortical and subcortical structures.
