Genetic variation in the renin-angiotensin system and response to endurance training

To investigate the relationship between genetic variation in the renin-angiotensin system and the effect of 12-week endurance training in Korean women.

Seventeen women who participated in an endurance training program for 12 weeks were genotyped for the angiotensinogen M235T polymorphism, angiotensin II type 1 receptor A1166C polymorphism, angiotensin-converting enzyme (ACE) T-3892C polymorphism, and angiotensin II type 2 receptor C3123A polymorphism. The following clinical parameters were measured before and after the endurance training program: blood pressure, body composition, ventilatory response, total cholesterol, triglyceride, and glucose.

Of the genetic markers investigated, the frequency of the T allele for the ACE T-3892C polymorphism was significantly associated with the response in body mass index and VO(2max) after 12 weeks of endurance training (p< 0.05). None of the other polymorphisms were significantly associated with the effect of training.

The significant association between ACE T-3892C and the change in body mass index and VO(2max) in Korean women are attributed to training, suggesting that this genetic variation is a useful genetic marker for clarifying the interindividual response to endurance training.